Endogenous nicotinic cholinergic activity regulates dopamine release in the striatum

被引:433
作者
Zhou, FM [1 ]
Liang, Y [1 ]
Dani, JA [1 ]
机构
[1] Baylor Coll Med, Div Neurosci, Houston, TX 77030 USA
关键词
D O I
10.1038/nn769
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Dopamine is vital for coordinated motion and for association learning linked to behavioral reinforcement. Here we show that the precise overlap of striatal dopaminergic and cholinergic fibers underlies potent control of dopamine release by ongoing nicotinic receptor activity. In mouse striatal slices, nicotinic antagonists or depletion of endogenous acetylcholine decreased evoked dopamine release by 90%. Nicotine at the concentration experienced by smokers also regulated dopamine release. In mutant mice lacking the beta2 nicotinic subunit, evoked dopamine release was dramatically suppressed, and those mice did not show cholinergic regulation of dopamine release. The results offer new perspectives when considering nicotine addiction and the high prevalence of smoking in schizophrenics.
引用
收藏
页码:1224 / 1229
页数:6
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