Human tumour viruses and the deregulation of cell polarity in cancer

被引：57

作者：

Banks, Lawrence ^{[1
]}

Pim, David ^{[1
]}

Thomas, Miranda ^{[1
]}

机构：

[1] Int Ctr Genet Engn & Biotechnol, I-34149 Trieste, Italy

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 12期

基金：

英国惠康基金;

关键词：

HUMAN-PAPILLOMAVIRUS E6; HEPATITIS-C-VIRUS; E-CADHERIN EXPRESSION; DOMAIN-BINDING MOTIF; EPITHELIAL-MESENCHYMAL TRANSITION; BETA-CATENIN; DISCS-LARGE; PDZ DOMAIN; KAPOSIS-SARCOMA; DOWN-REGULATION;

D O I：

10.1038/nrc3400

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The role of cell polarity regulators in the development of cancer has long been an enigma. Despite displaying characteristics of tumour suppressors, the core regulators of polarity are rarely mutated in tumours and there are few data from animal models to suggest that they directly contribute to cancer susceptibility, thus questioning their relevance to human carcinogenesis. However, a body of data from human tumour viruses is now providing compelling evidence of a central role for the perturbation of cell polarity in the development of cancer.

引用

页码：876 / 885

页数：10

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