Physostigmine antagonizes ketamine-induced noradrenaline release from the medial prefrontal cortex in rats

被引：21

作者：

Kubota, T ^{[1
]}

Hirota, K ^{[1
]}

Anzawa, N ^{[1
]}

Yoshida, H ^{[1
]}

Kushikata, T ^{[1
]}

Matsuki, A ^{[1
]}

机构：

[1] Hirosaki Univ, Sch Med, Dept Anesthesiol, Hirosaki, Aomori 0368216, Japan

来源：

BRAIN RESEARCH | 1999年 / 840卷 / 1-2期

关键词：

ketamine; physostigmine; medial prefrontal cortex; noradrenaline; rat;

D O I：

10.1016/S0006-8993(99)01793-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Physostigmine is known to antagonize ketamine anesthesia. In this study, effects of physostigmine (0.1 mg kg(-1) i.p.) on ketamine (100 mg kg(-1) i.p.)-induced anesthesia time and noradrenaline release from the medial prefrontal cortex in rats were examined. Ketamine produced anesthesia for 27 +/- 1 min and increased noradrenaline release to 405% of the basal. Physostigmine significantly reduced anesthesia time to 23 +/- 1 min(p < 0.05), and noradrenaline to 248% (p < 0.05). Therefore, noradrenaline release may play an important role in ketamine anesthesia. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：175 / 178

页数：4

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