Synthesis and Characterization of Novel Biodegradable Polyamides Containing -amino Acid

被引：14

作者：

Wang, Lingyun ^{[1
,2
]}

Wang, Yingjun ^{[2
]}

Cao, Derong ^{[1
]}

机构：

[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Peoples R China

[2] S China Univ Technol, Coll Mat Sci & Engn, Guangzhou 510640, Peoples R China

来源：

JOURNAL OF MACROMOLECULAR SCIENCE PART A-PURE AND APPLIED CHEMISTRY | 2009年 / 46卷 / 03期

关键词：

Drug release; interfacial polycondensation; polyamide; synthesis; thermal properties; POLY(ESTER AMIDE)S; GLYCINE RESIDUES; ADIPIC ACID; MONOMERS; POLYESTERAMIDES; DEGRADABILITY; DEGRADATION; FORMS;

D O I：

10.1080/10601320802637441

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The polyamides were obtained from 1,6-hexanediamine and diacylchloride which incorporated -amino acid residues through interfacial polycondensation. High molecular weight (inh = 1.05-1.18 dL/g) polymers were produced with high yields. The structure of polyamides was verified by FT-IR and 1H NMR spectra. They showed a remarkable ability to develop high crystallinity with melting temperatures in the range 117-191C and was stable up to 350C under nitrogen. Two methods such as alkali hydrolysis (10% NaOH w/v, 80C) and enzymatic hydrolysis were employed for assessing the susceptibility of these polyamides to degradation. A preliminary investigation of the 5-fluorouracil (5-FU) release characteristics of these polyamides showed that the release rate increased with increasing water absorption of the polymers.

引用

页码：312 / 320

页数：9

共 34 条

[1] Study on the degradability of poly(ester amide)s derived from the α-amino acids glycine, and L-alanine containing a variable amide/ester ratio [J].

Armelin, E ;

Paracuellos, N ;

Rodríguez-Galán, A ;

Puiggalí, J .

POLYMER, 2001, 42 (19) :7923-7932

[2] NOVEL COPOLYAMIDES BASED ON ADIPIC ACID, 1,6-HEXANEDIAMINE AND ALPHA-AMINO-ACIDS .2. STUDY OF PROPERTIES AND THEIR BIODEGRADABILITY FOR FOOD-PACKAGING APPLICATIONS [J].

ARVANITOYANNIS, I ;

PSOMIADOU, E ;

YAMAMOTO, N ;

NIKOLAOU, E ;

BLANSHARD, JMV .

POLYMER, 1995, 36 (15) :2957-2967

[3] NOVEL BIODEGRADABLE COPOLYAMIDES BASED ON ADIPIC ACID, BIS (P-AMINOCYCLOHEXYL) METHANE AND SEVERAL ALPHA-AMINO-ACIDS - SYNTHESIS, CHARACTERIZATION AND STUDY OF THEIR DEGRADABILITY FOR FOOD-PACKAGING APPLICATIONS .4. [J].

ARVANITOYANNIS, I ;

NIKOLAOU, E ;

YAMAMOTO, N .

POLYMER, 1994, 35 (21) :4678-4689

[4] NEW COPOLYAMIDES BASED ON ADIPIC ACID, ALIPHATIC DIAMINES AND AMINO-ACIDS - SYNTHESIS, CHARACTERIZATION AND BIODEGRADABILITY .5. [J].

ARVANITOYANNIS, I ;

NIKOLAOU, E ;

YAMAMOTO, N .

MACROMOLECULAR CHEMISTRY AND PHYSICS, 1995, 196 (04) :1129-1151

[5]

Bailey W.J., 1976, Proc. 3rd Int. Biodegradation Symp, P765

[6] GLYCINE RESIDUES INDUCE A HELICAL STRUCTURE IN POLYAMIDES [J].

BELLA, J ;

PUIGGALI, J ;

SUBIRANA, JA .

POLYMER, 1994, 35 (06) :1291-1297

[7] SYNTHESIS AND CHARACTERIZATION OF THE 2 CRYSTAL FORMS OF NYLON 2/12 [J].

BERMUDEZ, M ;

PUIGGALI, J ;

MUNOZGUERRA, S .

MACROMOLECULES, 1994, 27 (22) :6325-6334

[8]

Bou JJ, 1999, J POLYM SCI POL CHEM, V37, P983, DOI 10.1002/(SICI)1099-0518(19990401)37:7<983::AID-POLA13>3.0.CO

[9]

2-G

[10] Biosynthesis of polyamides containing amino acid residues through the specific aminolysis of amino acid ester derivatives [J].

Fan, Y ;

Chen, G ;

Tanaka, J ;

Tateishi, T .

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2004, 24 (6-8) :791-796

← 1 2 3 4 →