Putting the heat on ALS

被引:9
作者
Benn, SC [1 ]
Brown, RH [1 ]
机构
[1] Massachusetts Gen Hosp, Day Lab Neuromuscular Res, Charlestown, MA 02129 USA
关键词
D O I
10.1038/nm0404-345
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要
An enhancer of the heat shock response alleviates symptoms of neurodegeneration and prolongs lifespan in a mouse model of amyotrophic lateral sclerosis-even when administered after onset (pages 402-405).
引用
收藏
页码:345 / 347
页数:4
相关论文
共 15 条
[1]
Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease [J].
Allison, AC ;
Cacabelos, R ;
Lombardi, VRM ;
Alvarez, XA ;
Vigo, C .
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2001, 25 (07) :1341-1357
[2]
Bimoclomol (BRLP-42) ameliorates peripheral neuropathy in streptozotocin-induced diabetic rats [J].
Biro, K ;
Jednakovits, A ;
Kukorelli, T ;
Hegedus, E ;
Koranyi, L .
BRAIN RESEARCH BULLETIN, 1997, 44 (03) :259-263
[3]
Up-regulation of protein chaperones preserves viability of cells expressing toxic Cu/Zn-superoxide dismutase mutants associated with amyotrophic lateral sclerosis [J].
Bruening, W ;
Roy, J ;
Giasson, B ;
Figlewicz, DA ;
Mushynski, WE ;
Durham, HD .
JOURNAL OF NEUROCHEMISTRY, 1999, 72 (02) :693-699
[4]
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions [J].
Bruijn, LI ;
Becher, MW ;
Lee, MK ;
Anderson, KL ;
Jenkins, NA ;
Copeland, NG ;
Sisodia, SS ;
Rothstein, JD ;
Borchelt, DR ;
Price, DL ;
Cleveland, DW .
NEURON, 1997, 18 (02) :327-338
[5]
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice [J].
Clement, AM ;
Nguyen, MD ;
Roberts, EA ;
Garcia, ML ;
Boillée, S ;
Rule, M ;
McMahon, AP ;
Doucette, W ;
Siwek, D ;
Ferrante, RJ ;
Brown, RH ;
Julien, JP ;
Goldstein, LSB ;
Cleveland, DW .
SCIENCE, 2003, 302 (5642) :113-117
[6]
Bimoclomol, a heat shock protein co-inducer, acts by the prolonged activation of heat shock factor-1 [J].
Hargitai, J ;
Lewis, H ;
Boros, I ;
Rácz, T ;
Fiser, A ;
Kurucz, I ;
Benjamin, I ;
Vígh, L ;
Pénzes, Z ;
Csermely, P ;
Latchman, DS .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 307 (03) :689-695
[7]
The effect of treatment with BRX-220, a co-inducer of heat shock proteins, on sensory fibers of the rat following peripheral nerve injury [J].
Kalmar, B ;
Greensmith, L ;
Malcangio, M ;
McMahon, SB ;
Csermely, P ;
Burnstock, G .
EXPERIMENTAL NEUROLOGY, 2003, 184 (02) :636-647
[8]
Upregulation of heat shock proteins rescues motoneurones from axotomy-induced cell death in neonatal rats [J].
Kalmar, B ;
Burnstock, G ;
Vrbová, G ;
Urbanics, R ;
Csermely, P ;
Greensmith, L .
EXPERIMENTAL NEUROLOGY, 2002, 176 (01) :87-97
[9]
Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice [J].
Kieran, D ;
Kalmar, B ;
Dick, JRT ;
Riddoch-Contreras, J ;
Burnstock, G ;
Greensmith, L .
NATURE MEDICINE, 2004, 10 (04) :402-405
[10]
PHARMACOLOGICAL MODULATION OF HEAT-SHOCK FACTOR-1 BY ANTIINFLAMMATORY DRUGS RESULTS IN PROTECTION AGAINST STRESS-INDUCED CELLULAR-DAMAGE [J].
LEE, BS ;
CHEN, J ;
ANGELIDIS, C ;
JURIVICH, DA ;
MORIMOTO, RI .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7207-7211