Selective drug delivery to the colon using pectin:chitosan:hydroxypropyl methylcellulose film coated tablets

被引：79

作者：

Macleod, GS

Fell, JT ^{[1
]}

Collett, JH

Sharma, HL

Smith, AM

机构：

[1] Univ Manchester, Sch Pharm & Pharmaceut Sci, Manchester M13 9PL, Lancs, England

[2] Univ Manchester, Dept Med Biophys, Manchester M13 9PL, Lancs, England

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1999年 / 187卷 / 02期

关键词：

colonic delivery; pectin; chitosan; film coating; gamma scintigraphy;

D O I：

10.1016/S0378-5173(99)00196-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A study has been carried out to assess the potential of pectin:chilosan:hydroxypropyl methylcellulose (HPMC) (P:C:H) films for colonic drug delivery. Radiolabelled (Tc-99m) tablets were coated with a 3.1:1, P:C:H film and administered to human volunteers. The gastro-intestinal transit of the tablets was assessed by gamma scintigraphy. The results showed that in all cases (n = 4), the tablets were able to pass through the stomach and small intestine intact. Break up of the tablets commenced once they were in the colon, due to degradation of the coat by colonic bacteria. The study has highlighted the potential of this coating system for colonic drug delivery. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：251 / 257

页数：7

共 18 条

[1] Gastro-intestinal transit of a multiple-unit formulation (metoprolol CR/ZOK) and a non-disintegrating tablet with the emphasis on colon [J].