Reciprocal interactions between CA3 network activity and strength of recurrent collateral synapses

被引:109
作者
Bains, JS
Longacher, JM
Staley, KJ
机构
[1] Univ Colorado, Hlth Sci Ctr, Dept Neurol, Denver, CO 80262 USA
[2] Univ Colorado, Hlth Sci Ctr, Dept Pediat, Denver, CO 80262 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/11184
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In hippocampal slices, synchronous CA3 network activity induced persistent strengthening of active positive-feedback synapses. This altered network operation by increasing probability of future synchronous network activation. Long-term depression of synaptic strength induced by partial blockade of NMDA receptors during synchronous network activity reversed changes in probability of spontaneous network activation. These results suggest that specific network activity patterns selectively alter strength of active synapses. Stable, reversible alterations in network activity can also be effected by corresponding alterations in synaptic strength. These findings confirm the Hebb memory model at the neural-network level and suggest new therapies for pathological patterns of network activity in epilepsy.
引用
收藏
页码:720 / 726
页数:7
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