Joint American Academy of Dermatology-National Psoriasis Foundation guidelines of care for the management of psoriasis with systemic nonbiologic therapies

被引：242

作者：

Menter, Alan ^{[1
]}

Gelfand, Joel M. ^{[2
]}

Connor, Cody ^{[3
]}

Armstrong, April W. ^{[4
]}

Cordoro, Kelly M. ^{[5
]}

Davis, Dawn M. R. ^{[6
]}

Elewski, Boni E. ^{[3
]}

Gordon, Kenneth B. ^{[7
]}

Gottlieb, Alice B. ^{[7
]}

Kaplan, Daniel H. ^{[8
]}

Kavanaugh, Arthur ^{[9
]}

Kiselica, Matthew ^{[10
]}

Kivelevitch, Dario ^{[1
]}

Korman, Neil J. ^{[11
]}

Kroshinsky, Daniela ^{[12
]}

Lebwohl, Mark ^{[13
]}

Leonardi, Craig L. ^{[14
]}

Lichten, Jason ^{[10
]}

Lim, Henry W. ^{[15
]}

Mehta, Nehal N. ^{[16
]}

Paller, Amy S. ^{[17
]}

Parra, Sylvia L. ^{[18
]}

Pathy, Arun L. ^{[19
]}

Prater, Elizabeth Farley ^{[20
]}

Rahimi, Robert S. ^{[1
]}

Rupani, Reena N. ^{[1
]}

Siegel, Michael ^{[23
]}

Stoff, Benjamin ^{[21
]}

Strober, Bruce E. ^{[22
,23
]}

Tapper, Elliot B. ^{[24
]}

Wong, Emily B. ^{[25
]}

Wu, Jashin J. ^{[26
]}

Hariharan, Vidhya ^{[27
]}

Elmets, Craig A. ^{[3
]}

机构：

[1] Baylor Scott & White, Dallas, TX USA

[2] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Alabama Birmingham, Birmingham, AL USA

[4] Univ Southern Calif, Los Angeles, CA 90007 USA

[5] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA

[6] Mayo Clin, Rochester, MN USA

[7] Icahn Sch Med Mt Sinai, Dept Dermatol, New York, NY 10029 USA

[8] Univ Pittsburgh, Pittsburgh, PA 15260 USA

[9] Univ Calif San Diego, La Jolla, CA 92093 USA

[10] Natl Psoriasis Fdn, Portland, OR USA

[11] Univ Hosp Cleveland, Med Ctr, Cleveland, OH 44106 USA

[12] Massachusetts Gen Hosp, Boston, MA 02114 USA

[13] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[14] Cent Dermatol, St Louis, MO USA

[15] Henry Ford Hosp, Dept Dermatol, Detroit, MI 48202 USA

[16] NHLBI, NIH, Bldg 10, Bethesda, MD 20892 USA

[17] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[18] Dermatol & Skin Surg, Sumter, SC USA

[19] Colorado Permanente Med Grp, Centennial, CO USA

[20] Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA

[21] Emory Univ, Sch Med, Atlanta, GA USA

[22] Cent Connecticut Dermatol, Cromwell, CT USA

[23] Yale Univ, New Haven, CT USA

[24] Univ Michigan, Michigan Med, Ann Arbor, MI 48109 USA

[25] San Antonio Uniformed Serv Hlth Educ Consortium, Joint Base San Antonio, TX USA

[26] Dermatol Res & Educ Fdn, Irvine, CA USA

[27] Amer Acad Dermatol, Rosemont, PA USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2020年 / 82卷 / 06期

关键词：

Clinical guidelines for psoriasis; dermatology; nonbiologic systemic; psoriasis; psoriasis guidelines; skin disease; CHRONIC PLAQUE PSORIASIS; LOW-DOSE CYCLOSPORINE; PLACEBO-CONTROLLED TRIAL; JANUS KINASE INHIBITOR; RANDOMIZED CONTROLLED-TRIAL; ULTRAVIOLET-B PHOTOTHERAPY; INTERMITTENT SHORT COURSES; FUMARIC-ACID THERAPY; TO-SEVERE PSORIASIS; LONG-TERM TREATMENT;

D O I：

10.1016/j.jaad.2020.02.044

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Psoriasis is a chronic inflammatory disease involving multiple organ systems and affecting approximately 2% of the world's population. In this guideline, we focus the discussion on systemic, nonbiologic medications for the treatment of this disease. We provide detailed discussion of efficacy and safety for the most commonly used medications, including methotrexate, cyclosporine, and acitretin, and provide recommendations to assist prescribers in initiating and managing patients on these treatments. Additionally, we discuss newer therapies, including tofacitinib and apremilast, and briefly touch on a number of other medications, including fumaric acid esters (used outside the United States) and therapies that are no longer widely used for the treatment of psoriasis (ie, hydroxyurea, leflunomide, mycophenolate mofetil, thioguanine, and tacrolimus).

引用

页码：1445 / 1486

页数：42

共 218 条

[1]

Use of Apremilast in Combination With Other Therapies for Treatment of Chronic Plaque Psoriasis: A Retrospective Study [J].