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Getting your Pax straight: Pax proteins in development and disease

被引：379
作者：
Chi, N [1 ]
Epstein, JA [1 ]
机构：
[1] Univ Penn Hlth Syst, Div Cardiovasc, Philadelphia, PA 19104 USA
来源：
TRENDS IN GENETICS | 2002年 / 18卷 / 01期
关键词：
D O I：
10.1016/S0168-9525(01)02594-X
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The Pax gene family encodes a group of transcription factors that have been conserved through millions of years of evolution and play roles in early development. Pax proteins have been implicated as regulators of organogenesis and as key factors in maintaining pluripotency of stem cell populations during development. Mutations of the Pax genes cause profound developmental defects in organisms as diverse as flies, mice and humans. Here, we review crucial and illustrative roles of Pax gene products in cell-fate specification and developmental biology.
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页码：41 / 47
页数：7
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