Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period

被引:103
作者
Petersen, KF
Price, T
Cline, GW
Rothman, DL
Shulman, GI
机构
来源
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 1996年 / 270卷 / 01期
关键词
gluconeogenesis; nuclear magnetic resonance spectroscopy; glycogen;
D O I
10.1152/ajpendo.1996.270.1.E186
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Relative contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production during the first 12 h of a fast were studied in 13 healthy volunteers by noninvasively measuring hepatic glycogen content using C-13 nuclear magnetic resonance spectroscopy. Rates of net hepatic glycogenolysis were calculated by multiplying the change in liver glycogen content with liver volume determined by magnetic resonance imaging. Rates of gluconeogenesis were calculated as the difference between rates of glucose production determined with an infusion of [6,6-H-2]-glucose and net hepatic glycogenolysis. At 6 P.M. a liquid mixed meal (1,000 kcal; 60% as glucose) was given, to which [2-H-2]glucose was added to trace glucose absorption. Hepatic glycogen content was measured between 11 P.M. and 1 A.M. and between 3 and 6 A.M. At 11 P.M. the concentration was 470 mM and it decreased linearly during the night. The mean liver volume was 1.47 +/- 0.06 liters. Net hepatic glycogenolysis (5.8 +/- 0.8 mu mol . kg body wt(-1) . min(-1)) accounted for, on average, 45 +/- 6% and gluconeogenesis for 55 +/- 6% of the rate of whole body glucose production (12.6 +/- 0.6 mu mol . kg body wt(-1) . min(-1)). In conclusion, this study shows that, even early in the phase of the postabsorptive period when liver glycogen stores are maximal, gluconeogenesis contributes similar to 50% to hepatic glucose production.
引用
收藏
页码:E186 / E191
页数:6
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