Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins

被引：226

作者：

Rappuoli, R

Pizza, M

Douce, G

Dougan, G

机构：

[1] Chiron SPA, IRIS, I-53100 Siena, Italy

[2] Univ London Imperial Coll Sci Technol & Med, Dept Biochem, London SW7 2AZ, England

来源：

IMMUNOLOGY TODAY | 1999年 / 20卷 / 11期

关键词：

D O I：

10.1016/S0167-5699(99)01523-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Escherichia coli heat-labile enterotoxin and cholera toxin are potent mucosal immunogens and adjuvants in animal models. Nontoxic mutants retaining adjuvant activity are useful tools to dissect the mechanism of mucosal adjuvanticity and promising candidates far development of human vaccines and immunotherapy. Clinical trials are expected to proceed in the near future.

引用

收藏

页码：493 / 500

页数：8

相关论文

共 67 条

[1]

Ågren LC, 1999, J IMMUNOL, V162, P2432

[2]

Agren LC, 1997, J IMMUNOL, V158, P3936

[3] The adjuvants MF59 and LT-K63 enhance the mucosal and systemic immunogenicity of subunit influenza vaccine administered intranasally in mice [J].

Barchfeld, GL ;

Hessler, AL ;

Chen, M ;

Pizza, M ;

Rappuoli, R ;

Van Nest, GA .

VACCINE, 1999, 17 (7-8) :695-704

[4] Imaging the intracellular trafficking and state of the AB(5) quaternary structure of cholera toxin [J].

Bastiaens, PIH ;

Majoul, IV ;

Verveer, PJ ;

Soling, HD ;

Jovin, TM .

EMBO JOURNAL, 1996, 15 (16) :4246-4253

[5]

Blanchard TG, 1998, IMMUNOLOGY, V94, P22

[6] Fused polycationic peptide mediates delivery of diphtheria toxin A chain to the cytosol in the presence of anthrax protective antigen [J].

Blanke, SR ;

Milne, JC ;

Benson, EL ;

Collier, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) :8437-8442

[7] VIBRIO-CHOLERAE HEMAGGLUTININ PROTEASE NICKS CHOLERA ENTERO-TOXIN [J].

BOOTH, BA ;

BOESMANFINKELSTEIN, M ;

FINKELSTEIN, RA .

INFECTION AND IMMUNITY, 1984, 45 (03) :558-560

[8] Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor β1 and β2 chain expression [J].

Braun, MC ;

He, JP ;

Wu, CY ;

Kelsall, BL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (03) :541-552

[9] ROLE OF A POTENTIAL ENDOPLASMIC-RETICULUM RETENTION SEQUENCE (RDEL) AND THE GOLGI-COMPLEX IN THE CYTOTONIC ACTIVITY OF ESCHERICHIA-COLI HEAT-LABILE ENTEROTOXIN [J].

CIEPLAK, W ;

MESSER, RJ ;

KONKEL, ME ;

GRANT, CCR .

MOLECULAR MICROBIOLOGY, 1995, 16 (04) :789-800

[10] ADJUVANT ACTIVITY OF ESCHERICHIA-COLI HEAT-LABILE ENTERO-TOXIN AND EFFECT ON THE INDUCTION OF ORAL TOLERANCE IN MICE TO UNRELATED PROTEIN ANTIGENS [J].

CLEMENTS, JD ;

HARTZOG, NM ;

LYON, FL .

VACCINE, 1988, 6 (03) :269-277

← 1 2 3 4 5 6 7 →