α4β2 nACh rceptor pharmacophore models

被引:38
作者
Glennon, RA [1 ]
Dukat, M [1 ]
机构
[1] Virginia Commonwealth Univ, Sch Pharm, Dept Med Chem, Richmond, VA 23298 USA
关键词
D O I
10.1016/j.bmcl.2003.07.035
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Progress towards the development of alpha4beta2 nicotinic acetylcholinergic receptor pharmacophores is reviewed from the early Beers and Riech model to the newer vector models. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1841 / 1844
页数:4
相关论文
共 22 条
  • [1] Novel 3-pyridyl ethers with subnanomolar affinity for central neuronal nicotinic acetylcholine receptors
    Abreo, MA
    Lin, NH
    Garvey, DS
    Gunn, DE
    Hettinger, AM
    Wasicak, JT
    Pavlik, PA
    Martin, YC
    DonnellyRoberts, DL
    Anderson, DJ
    Sullivan, JP
    Williams, M
    Americ, SP
    Holladay, MW
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (04) : 817 - 825
  • [3] EFFECTS OF SOME ISOMERS AND ANALOGUES OF NICOTINE ON JUNCTIONAL TRANSMISSION
    BARLOW, RB
    HAMILTON, JT
    [J]. BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1962, 18 (03): : 510 - +
  • [4] STRUCTURE AND ACTIVITY OF ACETYLCHOLINE
    BEERS, WH
    REICH, E
    [J]. NATURE, 1970, 228 (5275) : 917 - &
  • [5] CALDWELL WS, 1997, INT BUS COMM S NIC A
  • [6] A theoretical study of epibatidine
    Campillo, N
    Páez, JA
    Alkorta, I
    Goya, P
    [J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1998, (12): : 2665 - 2669
  • [7] Synthesis, nicotinic acetylcholine receptor binding, and antinociceptive properties of 2-exo-2-(2′-substituted 5′-pyridinyl)-7-azabicyclo[2.2.1]heptanes.: Epibatidine analogues
    Carroll, FI
    Liang, F
    Navarro, HA
    Brieaddy, LE
    Abraham, P
    Damaj, MI
    Martin, BR
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (13) : 2229 - 2237
  • [8] Functional diversity among 5-substituted nicotine analogs; in vitro and in vivo investigations
    Dukat, M
    Damaj, IM
    Young, R
    Vann, R
    Collins, AC
    Marks, MJ
    Martin, BR
    Glennon, RA
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 435 (2-3) : 171 - 180
  • [9] (-)6-n-propylnicotine antagonizes the antinociceptive effects of (-)nicotine
    Dukat, M
    El-Zahabi, M
    Ferretti, F
    Damaj, MI
    Martin, BR
    Young, R
    Glennon, RA
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (20) : 3005 - 3007
  • [10] DUKAT M, 1994, MED CHEM RES, V4, P131