Rapid detection of mutations associated with macrolide resistance in Mycobacterium avium complex

被引：24

作者：

Nash, KA ^{[1
]}

Inderlied, CB ^{[1
]}

机构：

[1] UNIV SO CALIF,LOS ANGELES,CA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 07期

关键词：

D O I：

10.1128/AAC.40.7.1748

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Macrolide resistance in Mycobacterium avium can be detected with an adaption of a commercially available RNA/RNA duplex mismatch assay (Ambion, Austin, Tex,), The sensitivity and specificity values for the assay were 100% when evaluated against 41 macrolide-resistant and -susceptible strains of M. avium. Resistant subpopulations of similar to 20% could be readily detected, The assay is simple to perform and interpret, inexpensive, and rapid (<24-h turnaround).

引用

页码：1748 / 1750

页数：3

共 13 条

[1]

[Anonymous], BIAX PACK INS

[2]

BAKER RL, 1994, 34 INT C ANT AG CHEM, P210

[3] ACTIVITY OF CLARITHROMYCIN AGAINST MYCOBACTERIUM-AVIUM INFECTION IN PATIENTS WITH ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME - A CONTROLLED CLINICAL-TRIAL [J].