Copper(I) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand

被引：39

作者：

Atrian-Blasco, E. ^{[1
,2
,3
]}

Cerrada, E. ^{[3
]}

Conte-Daban, A. ^{[1
,2
]}

Testemale, D. ^{[4
,5
]}

Faller, P. ^{[1
,2
]}

Laguna, M. ^{[3
]}

Hureau, C. ^{[1
,2
]}

机构：

[1] CNRS, LCC, F-31077 Toulouse, France

[2] UPS, INPT, LCC, F-31077 Toulouse, France

[3] Univ Zaragoza, CSIC, Inst Sintesis Quim & Catalisis Homogenea, E-50009 Zaragoza, Spain

[4] Univ Grenoble Alpes, Inst NEEL, F-38000 Grenoble, France

[5] CNRS, Inst NEEL, F-38042 Grenoble, France

来源：

METALLOMICS | 2015年 / 7卷 / 08期

关键词：

METAL-IONS; A-BETA; COMPLEXES; CU; PEPTIDES;

D O I：

10.1039/c5mt00077g

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Copper(I) coordinating ligands in the Alzheimer's disease context have remained unexplored, despite the biological relevance of this redox state of the copper ion. Here, we show that the PTA ligand can remove copper from Ab, prevent reactive oxygen species production and oligomer formation, two deleterious events in the disease's etiology.

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收藏

页码：1229 / 1232

页数：4

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