Carbon nanotubes as intracellular transporters for proteins and DNA: An investigation of the uptake mechanism and pathway

被引：701

作者：

Kam, NWS ^{[1
]}

Liu, ZA ^{[1
]}

Dai, HJ ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 04期

关键词：

cellular uptake; DNA; drug delivery; endocytosis; nanotubes;

D O I：

10.1002/anie.200503389

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Endocytosis or not endocytosis: The pathway of the internalization of single-walled carbon nanotube (SWNT) conjugates into mammalian cells was determined to be energy-dependent endocytosis through clathrin-coated pits. (Figure Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：577 / 581

页数：5

相关论文

共 23 条

[1] Cationic carbon nanotubes bind to CpG oligodeoxynucleotides and enhance their immunostimulatory properties [J].

Bianco, A ;

Hoebeke, J ;

Godefroy, S ;

Chaloin, O ;

Pantarotto, D ;

Briand, JP ;

Muller, S ;

Prato, M ;

Partidos, CD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (01) :58-59

[2] HYPERTONIC MEDIA INHIBIT RECEPTOR-MEDIATED ENDOCYTOSIS BY BLOCKING CLATHRIN-COATED PIT FORMATION [J].

HEUSER, JE ;

ANDERSON, RGW .

JOURNAL OF CELL BIOLOGY, 1989, 108 (02) :389-400

[3] Nanotube molecular transporters: Internalization of carbon nanotube-protein conjugates into mammalian cells [J].

Kam, NWS ;

Jessop, TC ;

Wender, PA ;

Dai, HJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (22) :6850-6851

[4] Carbon nanotubes as intracellular protein transporters: Generality and biological functionality [J].

Kam, NWS ;

Dai, HJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (16) :6021-6026

[5] Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing [J].

Kam, NWS ;

Liu, Z ;

Dai, HJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (36) :12492-12493

[6] Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction [J].

Kam, NWS ;

O'Connell, M ;

Wisdom, JA ;

Dai, HJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (33) :11600-11605

[7] DEPLETION OF INTRACELLULAR POTASSIUM ARRESTS COATED PIT FORMATION AND RECEPTOR-MEDIATED ENDOCYTOSIS IN FIBROBLASTS [J].

LARKIN, JM ;

BROWN, MS ;

GOLDSTEIN, JL ;

ANDERSON, RGW .

CELL, 1983, 33 (01) :273-285

[8] Polyethylenimine-grafted multiwalled carbon nanotubes for secure noncovalent immobilization and efficient delivery of DNA [J].

Liu, Y ;

Wu, DC ;

Zhang, WD ;

Jiang, X ;

He, CB ;

Chung, TS ;

Goh, SH ;

Leong, KW .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, 44 (30) :4782-4785

[9]

LIU Y, 2005, ANGEW CHEM, V44, P4860

[10] RNA polymer translocation with single-walled carbon nanotubes [J].

Lu, Q ;

Moore, JM ;

Huang, G ;

Mount, AS ;

Rao, AM ;

Larcom, LL ;

Ke, PC .

NANO LETTERS, 2004, 4 (12) :2473-2477