The molecular toxicology of acetaminophen

被引：56

作者：

Josephy, PD ^{[1
]}

机构：

[1] Univ Guelph, Dept Mol & Cellular Biol, Guelph, ON N1G 2W1, Canada

来源：

DRUG METABOLISM REVIEWS | 2005年 / 37卷 / 04期

关键词：

actaminophen; hepatotoxicity; covalent binding; P450;

D O I：

10.1080/03602530500205200

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The history of the development of the analgestic drug acetaminophen is reviewed with an emphasis on the characteristics of its overdose toxicity. The P450-catalyzed oxidation of acetaminophen generates a reactive electrophile that binds covalently to proteins. Involvement of specific P450 enzymes in acetaminophen toxicity can be probed by experiments with knock-out mice. The identification of specific target proteins may help to clarify the mechanism of acetaminophen hepatoxocity.

引用

页码：581 / 594

页数：14

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