Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus

被引：86

作者：

Yau, JLW

Noble, J

Widdowson, J

Seckl, JR

机构：

[1] Molecular Endocrinology Laboratory, Molecular Medicine Centre, Western General Hospital

[2] University of Edinburgh, Molecular Medicine Centre, Western General Hospital, Edinburgh EH4 2XU, Crewe Road

来源：

MOLECULAR BRAIN RESEARCH | 1997年 / 45卷 / 01期

基金：

英国惠康基金;

关键词：

hippocampus; serotonin receptor; gene expression; glucocorticoid; metyrapone; aminoglutethimide;

D O I：

10.1016/S0169-328X(97)00026-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Both glucocorticoid excess and decreased serotonergic (5-HT) transmission may cause depression. The recently cloned 5-HT6 and 5-HT7 receptors have high affinity for antidepressants. Here, we show that pharmacological adrenalectomy increases 5-HT6 and 5-HT7 receptor mRNA expression in specific hippocampal subfields, effects partly reversed by corticosterone replacement. Increased 5-HT6 and 5-HT7 receptor expression may provide a basis, in part, for the therapeutic actions of adrenal steroid synthesis inhibitors in resistant depression. (C) 1997 Elsevier Science B.V. All rights reserved.

引用

页码：182 / 186

页数：5

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