Palmitoylcarnitine, a surface-active metabolite

被引：55

作者：

Goni, FM

Requero, MA

Alonso, A

机构：

[1] Grupo Biomembranas U. Asociada al C., Departamento de Bioquimica, Universidad del País Vasco, 48080 Bilbao

来源：

FEBS LETTERS | 1996年 / 390卷 / 01期

关键词：

carnitine; membrane leakage; membrane solubilization; mitochondrial fatty acid oxidation; carnitine palmitoyl transferase; myocardial ischemia;

D O I：

10.1016/0014-5793(96)00603-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Palmitoylcarnitine is a well-known intermediate in mitochondrial fatty acid oxidation. Less known are its properties as a surfactant, with a capacity to solubilize biological membranes similar to that of many synthetic detergents used in the biochemical laboratory. Some of the physico-chemical properties of palmitoylcarnitine may help to explain the need for coenzyme A-carnitine-coenzyme A acyl exchange during mitochondrial fatty acid import. The amphiphilic character of palmitoylcarnitine may also explain its proposed involvement in the pathogenesis of myocardial ischemia.

引用

页码：1 / 5

页数：5

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