Challenging assumptions about Alzheimer's disease: Mild cognitive impairment and the cholinergic hypothesis

被引:23
作者
Morris, JC [1 ]
机构
[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
[2] Washington Univ, Alzheimer Dis Res Ctr, St Louis, MO USA
关键词
D O I
10.1002/ana.10135
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
引用
收藏
页码:143 / 144
页数:2
相关论文
共 13 条
[1]   THE CHOLINERGIC HYPOTHESIS OF GERIATRIC MEMORY DYSFUNCTION [J].
BARTUS, RT ;
DEAN, RL ;
BEER, B ;
LIPPA, AS .
SCIENCE, 1982, 217 (4558) :408-417
[2]   POPULATION-BASED NORMS FOR THE MINI-MENTAL-STATE-EXAMINATION BY AGE AND EDUCATIONAL-LEVEL [J].
CRUM, RM ;
ANTHONY, JC ;
BASSETT, SS ;
FOLSTEIN, MF .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 269 (18) :2386-2391
[3]   Cholinergic markers in elderly patients with early signs of Alzheimer disease [J].
Davis, KL ;
Mohs, RC ;
Marin, D ;
Purohit, DP ;
Perl, DP ;
Lantz, M ;
Austin, G ;
Haroutunian, V .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 281 (15) :1401-1406
[4]   Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment [J].
DeKosky, ST ;
Ikonomovic, MD ;
Styren, SD ;
Beckett, L ;
Wisniewski, S ;
Bennett, DA ;
Cochran, EJ ;
Kordower, JH ;
Mufson, EJ .
ANNALS OF NEUROLOGY, 2002, 51 (02) :145-155
[5]   Cholinesterase inhibitors for Alzheimer's disease [J].
Grutzendler, J ;
Morris, JC .
DRUGS, 2001, 61 (01) :41-52
[6]  
Kordower JH, 2001, ANN NEUROL, V49, P202, DOI 10.1002/1531-8249(20010201)49:2<202::AID-ANA40>3.0.CO
[7]  
2-3
[8]   Mild cognitive impairment represents early-stage Alzheimer disease [J].
Morris, JC ;
Storandt, M ;
Miller, JP ;
McKeel, DW ;
Price, JL ;
Rubin, EH ;
Berg, L .
ARCHIVES OF NEUROLOGY, 2001, 58 (03) :397-405
[9]   Cerebral amyloid deposition and diffuse plaques in ''normal'' aging: Evidence for presymptomatic and very mild Alzheimer's disease [J].
Morris, JC ;
Storandt, M ;
McKeel, DW ;
Rubin, EH ;
Price, JL ;
Grant, EA ;
Berg, L .
NEUROLOGY, 1996, 46 (03) :707-719
[10]   Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease [J].
Morris, JC ;
Price, JL .
JOURNAL OF MOLECULAR NEUROSCIENCE, 2001, 17 (02) :101-118