Emerging medicinal roles for lysophospholipid signaling

被引:214
作者
Gardell, SE [1 ]
Dubin, AE [1 ]
Chun, J [1 ]
机构
[1] Scripps Res Inst, Helen L Dorris Child & Adolescent Neuropsychiat D, Dept Mol Biol, La Jolla, CA 92037 USA
关键词
D O I
10.1016/j.molmed.2005.12.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The two lysophospholipids (LPs) lysophosphatidic acid and sphingosine 1-phosphate (S1P) regulate diverse biological processes. Over the past decade, it has become clear that medically relevant LP activities are mediated by specific G protein-coupled receptors, implicating them in the etiology of a growing number of disorders. A new class of LP agonists shows promise for drug therapy: the experimental drug FTY720 is phosphorylated in vivo to produce a potent S1P receptor agonist (FTY720-P) and is currently in Phase III clinical trials for kidney transplantation and Phase II for multiple sclerosis. Recent genetic and pharmacological studies on LP signaling in animal disease models have identified new areas in which interventions in LP signaling might provide novel therapeutic approaches for the treatment of human diseases.
引用
收藏
页码:65 / 75
页数:11
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