Interleukin 3 activates not only JAK2 and STAT5, but also Tyk2, STAT1, and STAT3

被引：27

作者：

Nagata, Y ^{[1
]}

Todokoro, K ^{[1
]}

机构：

[1] RIKEN,INST PHYS & CHEM RES,TSUKUBA LIFE SCI CTR,TSUKUBA,IBARAKI 305,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 221卷 / 03期

关键词：

D O I：

10.1006/bbrc.1996.0674

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It has been described that interleukin 3 (IL3) activates JAK2, which in rum stimulates STAT5 activation. We found, however, that IL3 induces tyrosine-phosphorylation of Tyk2 as well as JAK2 in IL3-dependent mouse cell lines, FDC-P2 and Ba/F3. Furthermore, we found that IL3 induces activation of not only STAT5 but also STAT1 and STAT3. Taken together with other observations, these results indicate that IL3, erythropoietin and thrombopoietin share a common JAK-STAT signaling pathway. (C) 1996 Academic Press, Inc.

引用

页码：785 / 789

页数：5

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