Developmental biology of the pancreas: A comprehensive review

被引：324

作者：

Gittes, George K. ^{[1
,2
]}

机构：

[1] Childrens Hosp Pittsburgh, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Sch Med, Dept Pediat Surg, Pittsburgh, PA 15213 USA

来源：

DEVELOPMENTAL BIOLOGY | 2009年 / 326卷 / 01期

关键词：

HEPATOCYTE GROWTH-FACTOR; GLUCAGON-LIKE PEPTIDE-1; CELL-SPECIFIC TRANSCRIPTION; INSULIN GENE-TRANSCRIPTION; DEVELOPING MOUSE PANCREAS; NUCLEAR FACTOR 3-BETA; DNA-BINDING ACTIVITY; ISLET DIFFERENTIATION PROGRAM; HEDGEHOG SIGNALING REGULATION; BONE MORPHOGENETIC PROTEIN;

D O I：

10.1016/j.ydbio.2008.10.024

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Pancreatic development represents a fascinating process in which two morphologically distinct tissue types must derive from one simple epithelium. These two tissue types, exocrine (including acinar cells, centro-acinar cells, and ducts) and endocrine cells serve disparate functions, and have entirely different morphology. In addition, the endocrine tissue must become disconnected from the epithelial lining during its development. The pancreatic development field has exploded in recent years, and numerous published reviews have dealt specifically with only recent findings, or specifically with certain aspects of pancreatic development. Here I wish to present a more comprehensive review of all aspects of pancreatic development, though still there is not a room for discussion of stem cell differentiation to pancreas, nor for discussion of post-natal regeneration phenomena, two important fields closely related to pancreatic development. (C) 2008 Published by Elsevier Inc.

引用

页码：4 / 35

页数：32

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