Synthesis of a complementary dimer from mono(imidazolyl)-substituted cobalt(II) porphyrin as a new artificial T-form hemoglobin

被引：16

作者：

Inaba, Y ^{[1
]}

Kobuke, Y ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Mat Sci, Ikoma 6300192, Japan

来源：

TETRAHEDRON | 2004年 / 60卷 / 13期

基金：

日本科学技术振兴机构;

关键词：

artificial hemoglobin; porphyrin dimer; picket fence cobalt porphyrin; dioxygen binding; oxygen affinity;

D O I：

10.1016/j.tet.2004.01.066

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mono(imidazolyl)- substituted Co(H) porphyrin dimer with a 'picket fence' structure was synthesized as a new artificial hemoglobin model containing two binding sites. The dimer was confirmed by UV-vis, resonance Raman and ESR spectral measurements to bind two dioxygen molecules reversibly. The dioxygen binding affinity of the dimer was lower than that of the corresponding monomer. The decrease in this affinity is discussed in terms of steric hindrance and orientational effect of the axial ligand. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3097 / 3107

页数：11

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