Toward molecular diagnostics of mood disorders in psychiatry

被引:34
作者
Avissar, S [1 ]
Schreiber, G
机构
[1] Ben Gurion Univ Negev, Dept Clin Pharmacol, IL-84105 Beer Sheva, Israel
[2] Ben Gurion Univ Negev, Dept Psychiat, IL-84105 Beer Sheva, Israel
关键词
D O I
10.1016/S1471-4914(02)02351-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mental disorders are highly prevalent and often difficult to diagnose. There is a significant gap between advances in their pharmacotherapy and the present lack of objective biologic tests for diagnosis. The special complexity of diagnosis in psychiatry is related to the absence of objective diagnostic 'gold standards', co-morbidity, heterogeneity and equifinality, quantitative trait loci, and focus heterogeneity. Here, we review recent findings relating to diagnostic, pathophysiological, and linkage markers for mood disorders at the biochemical level involving monoamine neurotransmitters, hormones, and signal-transducing G proteins. Identification of biological diagnostic markers could enable segregating mood disorders to several biologically different subtypes. New-era methods and strategies involving genomics, proteomics, multi-marker approach and single nucleotide polymorphisms have the potential to revolutionize future diagnosis in psychiatry.
引用
收藏
页码:294 / 300
页数:7
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