C-reactive protein (CRP) increases VEGF-A expression in monocytic cells via a PI3-kinase and ERK 1/2 signaling dependent pathway

被引:32
作者
Bello, Gaele [1 ,2 ]
Cailotto, Frederic [1 ,2 ]
Hanriot, Didier [1 ,2 ]
Kolopp-Sarda, Marie-Nathalle [3 ]
Latger-Cannard, Veronique [4 ]
Hess, Ketsia [1 ,2 ]
Zannad, Faiez [1 ,2 ]
Lonorois, Dan [1 ,2 ,5 ]
Ropars, Armelle [1 ,2 ]
机构
[1] INSERM, U684, F-54500 Vandoeuvre Les Nancy, France
[2] Univ Nancy 1, F-54500 Vandoeuvre Les Nancy, France
[3] CHU Vandoeuvre Nancy, Immunol Lab, F-54500 Vandoeuvre Les Nancy, France
[4] CHU Vandoeuvre Nancy, Dept Biol Haematol, F-54500 Vandoeuvre Les Nancy, France
[5] CHU Vandoeuvre Nancy, Dept Anaesthesia & Intens Care, F-54500 Vandoeuvre Les Nancy, France
关键词
C-reactive protein; VEGF; Atherosclerosis; MAP kinase;
D O I
10.1016/j.atherosclerosis.2007.12.046
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
C-reactive protein (CRP) is an independent predictor of atherosclerosis and its complications. Monocytes/macrophages are implicated in this complex disease which is, among other mechanisms, characterised by angiogenesis. The aim of this study was to analyse whether CRP plays a role in VEGF-A regulation by monocytic cells. Out findings show that CRP up-regulates VEGF-A mRNA expression and protein excretion in THP-1 cells in a concentration- and time-dependent manner. Furthermore. We studied the signaling pathway underlying this effect. CRP increases VEGF-A expression via a PI3-kinase and an extracellular-signal-regulated kinase (ERK) 1/2 dependent pathway. Our results suggest that CRP could play a role in the angiogenesis process via immune cells such as monocytes. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:286 / 293
页数:8
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