Hemocompatible Polyethylene Glycol Films on Silicon

被引：42

作者：

Zhang, Miqin ^{[1
,2
]}

Ferrari, Mauro ^{[1
,2
,3
]}

机构：

[1] Univ Calif Berkeley, Biomed Microdevices Ctr, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Mat Sci & Mineral Engn, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Civil & Environm Engn, Berkeley, CA 94720 USA

来源：

BIOMEDICAL MICRODEVICES | 1998年 / 1卷 / 01期

关键词：

self-assembled; surface modification; silicon; PEG; ESCA; hemocompatibility;

D O I：

10.1023/A:1009938507935

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A simple hemocompatibility-enhancing technique for immobilizing a self-assembled polyethylene glycol multilayer onto silicon surfaces is introduced. It involves the functionalization of PEG by SiCl3 groups on its chain ends, and the reaction of the PEG organosilicon derivatives with hydroxylated groups on silicon surfaces. Surface properties of the treated surfaces were characterized by contact angle measurement, electron spectroscopy for chemical analysis, and ellipsometry. The coated PEG self-assembled molecular film showed effective suppression in both plasma protein adsorption and platelet adhesion to silicon surfaces.

引用

页码：81 / 89

页数：9

共 35 条

[1] SURFACE MODIFICATION OF POLYMERIC BIOMATERIALS WITH POLY(ETHYLENE OXIDE), ALBUMIN, AND HEPARIN FOR REDUCED THROMBOGENICITY [J].