Transforming Growth Factor-β Signaling in Immunity and Cancer

被引：1983

作者：

Batlle, Eduard ^{[1
,2
,3
]}

Massague, Joan ^{[4
]}

机构：

[1] Barcelona Inst Sci & Technol, Inst Res Biomed IRB Barcelona, Baldiri Reixac 10, Barcelona 08028, Spain

[2] Ctr Invest Biomed Red Canc CIBERONC, Barcelona, Spain

[3] ICREA, Passeig Lluis Co 23, Barcelona 08010, Spain

[4] Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, Canc Biol & Genet Program, New York, NY 10065 USA

来源：

IMMUNITY | 2019年 / 50卷 / 04期

基金：

欧洲研究理事会;

关键词：

REGULATORY T-CELLS; LATENT TGF-BETA; CLASS-II TRANSACTIVATOR; MYELOID CELLS; DOWN-REGULATION; COLON-CANCER; IFN-GAMMA; NK CELLS; SURFACE EXPRESSION; TUMOR PROGRESSION;

D O I：

10.1016/j.immuni.2019.03.024

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Transforming growth factor (TGF)-beta is a crucial enforcer of immune homeostas's -Ind tolerance, inhibiting the expansion and function of many components of the immune system. Perturbations in TGF-beta signaling under-lie inflammatory diseases and promote tumor emergence. TGF-beta is also central to immune suppression within the tumor microenvironment, and recent studies have revealed roles in tumor immune evasion and poor responses to cancer immunotherapy. Here, we present an overview of the complex biology of the TGF-beta family and its context-dependent nature. Then, focusing on cancer, we discuss the roles of TGF-beta signaling in distinct immune cell types and how this knowledge is being leveraged to unleash the immune system against the tumor.

引用

页码：924 / 940

页数：17

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