Gene therapy: Progress, problems, prospects.

被引:31
作者
Blau, H
Khavari, P
机构
[1] STANFORD UNIV,SCH MED,DEPT DERMATOL,STANFORD,CA 94305
[2] VET AFFAIRS PALO ALTO,STANFORD,CA 94305
关键词
D O I
10.1038/nm0697-612
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A recent meeting highlights the progress and the challenges of gene therapy.
引用
收藏
页码:612 / 613
页数:2
相关论文
共 8 条
[1]  
BOHL D, 1997, NAT MED, V3, P229
[2]   Complexes of adenovirus with polycationic polymers and cationic lipids increase the efficiency of gene transfer in vitro and in vivo [J].
Fasbender, A ;
Zabner, J ;
Chillon, M ;
Moninger, TO ;
Puga, AP ;
Davidson, BL ;
Welsh, MJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) :6479-6489
[3]   Recombinant adeno-associated virus for muscle directed gene therapy [J].
Fisher, KJ ;
Jooss, K ;
Alston, J ;
Yang, YP ;
Haecker, SE ;
High, K ;
Pathak, R ;
Raper, SE ;
Wilson, JM .
NATURE MEDICINE, 1997, 3 (03) :306-312
[4]   Insertion of the adenoviral E3 region into a recombinant viral vector prevents antiviral humoral and cellular immune responses and permits long-term gene expression [J].
Ilan, Y ;
Droguett, G ;
Chowdhury, NR ;
Li, YA ;
Sengupta, K ;
Thummala, NR ;
Davidson, A ;
Chowdhury, JR ;
Horwitz, MS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) :2587-2592
[5]   LONG-TERM HEPATIC ADENOVIRUS-MEDIATED GENE-EXPRESSION IN MICE FOLLOWING CTLA4LG ADMINISTRATION [J].
KAY, MA ;
HOLTERMAN, AX ;
MEUSE, L ;
GOWN, A ;
OCHS, HD ;
LINSLEY, PS ;
WILSON, CB .
NATURE GENETICS, 1995, 11 (02) :191-197
[6]   Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors [J].
Koeberl, DD ;
Alexander, IE ;
Halbert, CL ;
Russell, DW ;
Miller, AD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (04) :1426-1431
[7]   Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector [J].
Naldini, L ;
Blomer, U ;
Gage, FH ;
Trono, D ;
Verma, IM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) :11382-11388
[8]   Amelioration of the dystrophic phenotype of mdx mice using a truncated utrophin transgene [J].
Tinsley, JM ;
Potter, AC ;
Phelps, SR ;
Fisher, R ;
Trickett, JI ;
Davies, KE .
NATURE, 1996, 384 (6607) :349-353