Medication use modifies the health effects of particulate sulfate air pollution in children with asthma

被引:15
作者
Peters, A
Dockery, DW
Heinrich, J
Wichmann, HE
机构
[1] GSF FORSCHUNGSZENTRUM UMWELT & GESUNDHEIT GMBH,INST EPIDEMIOL,NEUHERBERG,GERMANY
[2] HARVARD UNIV,SCH PUBL HLTH,DEPT ENVIRONM HLTH,ENVIRONM EPIDEMIOL PROGRAM,BOSTON,MA 02115
[3] UNIV MUNICH,LEHRSTUHL EPIDEMIOL,INST MED INFORMAT VERARBEITUNG BIOMETRIE & EPIDEM,MUNICH,GERMANY
关键词
air pollution; asthma; asthma medication; beta2-agonist; children; particles; peak expiratory flow; respiratory symptoms; sulfates;
D O I
10.2307/3433341
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Previous controlled studies have indicated that asthma medication modifies the adverse effects of sulfur dioxide (SO2) on lung function and asthma symptoms. Th present report analyzed the role of medication use in a panel study of children with mild asthma. Children from Sokolov (n = 82) recorded daily peak expiratory flow (PEF) measurements, symptoms, and medication use in a diary. Linear and logistic regression analyses estimated the impact of concentrations of sulfate particles with diameters less than 2.5 mu m, adjusting for linear trend, mean temperature, weekend (versus weekday), and prevalence of fever in the sample. Fifty-one children took no asthma medication, and only 31 were current medication users. Most children were treated with theophylline; only nine used sprays containing beta-agonist. For the nonmedicated children, weak associations between a 5-day mean of sulfates and respiratory symptoms were observed. Medicated children, in contrast, increased their beta-agonist use in direct association with an increase in 5-day mean of sulfates, but medication use did not prevent decreases in PEF and increases in the prevalence of cough attributable to particulate air pollution. Medication use was not a confounder but attenuated the associations between particulate air pollution and health outcomes.
引用
收藏
页码:430 / 435
页数:6
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