Involvement of the cylindrical inclusion (CI) protein in the overcoming of an eIF4E-mediated resistance against Lettuce mosaic potyvirus

被引：63

作者：

Abdul-Razzak, Anas ^{[1
]}

Guiraud, Thomas ^{[1
]}

Peypelut, Martine ^{[1
]}

Walter, Jocelyne ^{[1
]}

Houvenaghel, Marie-Christine ^{[1
]}

Candresse, Thierry ^{[1
]}

Le Gall, Olivier ^{[1
]}

German-Retana, Sylvie ^{[1
]}

机构：

[1] Univ Bordeaux 2, INRA, UMR 1090, GDPP, F-33883 Villenave Dornon, France

来源：

MOLECULAR PLANT PATHOLOGY | 2009年 / 10卷 / 01期

关键词：

INITIATION-FACTOR EIF4E; RNA HELICASE; BIOLOGICAL-PROPERTIES; ESCHERICHIA-COLI; CODING REGION; VIRUS LMV; VPG; GENOME; IDENTIFICATION; PATHOGENICITY;

D O I：

10.1111/j.1364-3703.2008.00513.x

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The capacity of Lettuce mosaic virus to overcome the lettuce resistance conferred by the mo1(1) and mo1(2) alleles of the gene for eukaryotic translation initiation factor 4E (eIF4E) was analysed using reverse genetics. Mutations in the virus genome-linked protein (VPg) allowed mo1(1) only to be overcome, but mutations in the C-terminal portion of the cylindrical inclusion (CI) protein allowed both alleles to be overcome. Site-directed mutagenesis pinpointed a key role of the amino acid at position 621 in the virulence. This is the first example of the involvement of a potyviral CI protein in the breaking of an eIF4E-mediated resistance.

引用

页码：109 / 113

页数：5

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