Preparation and evaluation of pectin beads

被引：57

作者：

Aydin, Z

Akbuga, J

机构：

[1] University of Marmara, Faculty of Pharmacy, Dept. of Pharmaceutical Technology, 81010 Haydarpaşa, Istanbul

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1996年 / 137卷 / 01期

关键词：

beads; pectin; ionotropic gelation; Atenolol; piroxicam; sustained-release;

D O I：

10.1016/0378-5173(95)04458-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Pectin beads were prepared by dropping drug-containing solutions of pectin into calcium chloride solutions. The droplets instantaneously formed gelled spheres by ionotropic gelation. Atenolol (cationic) and piroxicam (anionic) were used as model drugs. By using this method, beads with high drug contents were obtained. The effect of formulation and processing factors was also studied.

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页码：133 / 136

页数：4

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