Regulation of translation initiation following stress

被引:98
作者
Sheikh, MS [1 ]
Fornace, AJ [1 ]
机构
[1] NCI, Div Basic Sci, NIH, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
translation initiation; eIF2; eIF3; eIF5; eIF1(A121/SU11); translation checkpoints;
D O I
10.1038/sj.onc.1203131
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent studies suggest that genotoxic and non-genotoxic stresses appear to invoke translational checkpoints in order,to inhibit protein synthesis. Depending on the stress and/or cell type, this downregulation of protein synthesis may either (i) protect against the deleterious effects of noxious agents and ensure the conservation of resources that are needed to survive under adverse conditions or (ii) activate apoptosis, In this article, we have reviewed several lines of evidence which support the notion that regulation of translation initiation is an important component of the cellular stress response. While the stress-induced post-translational regulation of translation initiation factors (eIFs) has been well documented, stress-induced regulation of eIFs at the mRNA levels, as review ed here, is only beginning to be elucidated. Thus, the stress-mediated regulation of eIFs occurs at multiple different levels involving, transcriptional, post-transcriptional and post-translational controls.
引用
收藏
页码:6121 / 6128
页数:8
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