An Epigenetic Role for Maternally Inherited piRNAs in Transposon Silencing
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作者:
Brennecke, Julius
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Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Brennecke, Julius
[1
]
Malone, Colin D.
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Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Malone, Colin D.
[1
]
Aravin, Alexei A.
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Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Aravin, Alexei A.
[1
]
Sachidanandam, Ravi
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Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Sachidanandam, Ravi
[1
]
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Stark, Alexander
[2
,3
,4
]
Hannon, Gregory J.
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Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Hannon, Gregory J.
[1
]
机构:
[1] Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
[2] MIT, Broad Inst, Cambridge, MA 02141 USA
[3] Harvard Univ, Broad Inst, Cambridge, MA 02141 USA
[4] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA
In plants and mammals, small RNAs indirectly mediate epigenetic inheritance by specifying cytosine methylation. We found that small RNAs themselves serve as vectors for epigenetic information. Crosses between Drosophila strains that differ in the presence of a particular transposon can produce sterile progeny, a phenomenon called hybrid dysgenesis. This phenotype manifests itself only if the transposon is paternally inherited, suggesting maternal transmission of a factor that maintains fertility. In both P- and I- element- mediated hybrid dysgenesis models, daughters show a markedly different content of Piwi- interacting RNAs ( piRNAs) targeting each element, depending on their parents of origin. Such differences persist from fertilization through adulthood. This indicates that maternally deposited piRNAs are important for mounting an effective silencing response and that a lack of maternal piRNA inheritance underlies hybrid dysgenesis.
机构:
Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Aravin, Alexei A.
Hannon, Gregory J.
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Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Hannon, Gregory J.
Brennecke, Julius
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Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
机构:
Univ Sao Paulo, Dept Biol, Lab Mol Evolut Insects, IBILCE, BR-15054000 Sao Jose do Rio Preto, SP, BrazilUniv Sao Paulo, Dept Biol, Lab Mol Evolut Insects, IBILCE, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
Castro, JP
Carareto, CMA
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Univ Sao Paulo, Dept Biol, Lab Mol Evolut Insects, IBILCE, BR-15054000 Sao Jose do Rio Preto, SP, BrazilUniv Sao Paulo, Dept Biol, Lab Mol Evolut Insects, IBILCE, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
机构:
Inst Gustave Roussy, CNRS, UMR 8122, Unite Retrovirus Endogenes & Elements Retroides E, Villejuif, FranceInst Gustave Roussy, CNRS, UMR 8122, Unite Retrovirus Endogenes & Elements Retroides E, Villejuif, France
Dramard, Xavier
Heidmann, Thierry
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Inst Gustave Roussy, CNRS, UMR 8122, Unite Retrovirus Endogenes & Elements Retroides E, Villejuif, FranceInst Gustave Roussy, CNRS, UMR 8122, Unite Retrovirus Endogenes & Elements Retroides E, Villejuif, France
Heidmann, Thierry
Jensen, Silke
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Inst Gustave Roussy, CNRS, UMR 8122, Unite Retrovirus Endogenes & Elements Retroides E, Villejuif, FranceInst Gustave Roussy, CNRS, UMR 8122, Unite Retrovirus Endogenes & Elements Retroides E, Villejuif, France
机构:
Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Aravin, Alexei A.
Hannon, Gregory J.
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h-index: 0
机构:
Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
Hannon, Gregory J.
Brennecke, Julius
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机构:
Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USACold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA
机构:
Univ Sao Paulo, Dept Biol, Lab Mol Evolut Insects, IBILCE, BR-15054000 Sao Jose do Rio Preto, SP, BrazilUniv Sao Paulo, Dept Biol, Lab Mol Evolut Insects, IBILCE, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
Castro, JP
Carareto, CMA
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h-index: 0
机构:
Univ Sao Paulo, Dept Biol, Lab Mol Evolut Insects, IBILCE, BR-15054000 Sao Jose do Rio Preto, SP, BrazilUniv Sao Paulo, Dept Biol, Lab Mol Evolut Insects, IBILCE, BR-15054000 Sao Jose do Rio Preto, SP, Brazil
机构:
Inst Gustave Roussy, CNRS, UMR 8122, Unite Retrovirus Endogenes & Elements Retroides E, Villejuif, FranceInst Gustave Roussy, CNRS, UMR 8122, Unite Retrovirus Endogenes & Elements Retroides E, Villejuif, France
Dramard, Xavier
Heidmann, Thierry
论文数: 0引用数: 0
h-index: 0
机构:
Inst Gustave Roussy, CNRS, UMR 8122, Unite Retrovirus Endogenes & Elements Retroides E, Villejuif, FranceInst Gustave Roussy, CNRS, UMR 8122, Unite Retrovirus Endogenes & Elements Retroides E, Villejuif, France
Heidmann, Thierry
Jensen, Silke
论文数: 0引用数: 0
h-index: 0
机构:
Inst Gustave Roussy, CNRS, UMR 8122, Unite Retrovirus Endogenes & Elements Retroides E, Villejuif, FranceInst Gustave Roussy, CNRS, UMR 8122, Unite Retrovirus Endogenes & Elements Retroides E, Villejuif, France