Dexamethasone increases leptin expression in humans in vivo

被引：155

作者：

PapaspyrouRao, S

Schneider, SH

Petersen, RN

Fried, SK

机构：

[1] RUTGERS STATE UNIV, COOK COLL, DEPT NUTR SCI, NEW BRUNSWICK, NJ 08903 USA

[2] UNIV MED & DENT NEW JERSEY, ROBERT WOOD JOHNSON MED SCH, DIV ENDOCRINOL, NEW BRUNSWICK, NJ 08903 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1997年 / 82卷 / 05期

关键词：

D O I：

10.1210/jc.82.5.1635

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effect of 2 days of oral dexamethasone administration (0.75 mg twice daily) on leptin expression in healthy volunteers was tested. Dexamethasone increased the relative abundance of leptin messenger RNA in abdominal and gluteal adipose tissues by approximately 70% (P < 0.05). Dexamethasone also significantly increased serum leptin (+ 80%) and insulin concentration(+ 83%) but did not affect serum glucose. We conclude that a hypercortisolemic/hyperinsulinemic state up-regulates leptin expression at the messenger RNA level in humans.

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页码：1635 / 1637

页数：3

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