Sesquiterpenes from the Hainan sponge Dysidea septosa

被引：40

作者：

Huang, Xiao-Chun ^{[1
]}

Li, Jia ^{[1
]}

Li, Zhen-Yu ^{[1
]}

Shi, Lei ^{[1
]}

Guo, Yue-Wei ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 08期

关键词：

D O I：

10.1021/np8002035

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Five new sesquiterpenes. named lingshuiolides A (1) and B (2), lingshuiperoxide (6), isodysetherin (10), and spirolingshuiolide (12), along with several known related analogues (7-9, 11 and 13-15), were isolated from the Hainan marine sponge Dysidea septosa. The structures of new compounds 1, 2, 6 10, and 12 were determined by detailed analysis of 1D and 2D NMR spectra and by comparison with related model compounds. The absolute configuration of lingshuiolide B (2) was established by using the modified Mosher's method. Spirolingshuiolide (12) represents the first example of a sesquiterpene with a rearranged drimane skeleton. Compounds 7-9 and 15 exhibited significant inhibitory activity against human protein tyrosine phosphatase 1B (hPTP1B), an enzyme involved in the regulation of insulin signaling. In particular, 15 showed the most potent effect, with ail IC(50) value of 1.9 mu g/mL.

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页码：1399 / 1403

页数：5

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