Chemokine receptor expression and function in childhood acute lymphoblastic leukemia of B-lineage

被引：25

作者：

Corcione, A

Arduino, N

Ferretti, E

Pistorio, A

Spinelli, M

Ottonello, L

Dallegri, F

Basso, G

Pistoia, V

机构：

[1] Ist Giannina Gaslini, Lab Oncol, I-16148 Genoa, Italy

[2] Univ Genoa, Dept Internal Med, Lab Phagocyte Physiopathol & Inflammat, I-16126 Genoa, Italy

[3] G Gaslini Inst Children, Sci Direct, Clin Epidemiol & Biometry Unit, Genoa, Italy

[4] Univ Padua, Dept Pediat, Div Hematol Oncol, Padua, Italy

来源：

LEUKEMIA RESEARCH | 2006年 / 30卷 / 04期

关键词：

B-lineage acute lymphoblastic leukemia; chemokines; chemokine receptors; chemotaxis;

D O I：

10.1016/j.leukres.2005.07.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Scanty information is available on chemokine receptor expression and function in childhood B-lineage acute lymphoblastic leukemia (ALL). Thirteen pro-B, 17 early pre-B, 12 pre-B, and 9 B-ALL/Burkitt lymphoma (BL) pediatric cases were tested for CXCR1 to CXCR5 and CCR1 to CCR7 expression. CXCR2, CXCR3, and CXCR4 were expressed in the majority of cases, while the other receptors were variably expressed or absent. CXCR4 mediated chemotaxis of all leukemic cell subtypes. Freshly isolated CCR7(+) early pre-B-ALL cells migrated to CCL19, whereas CCR7(+) pro-B- and pre-B-ALL cells were attracted by CCL19 only following culture with soluble recombinant CD40 ligand. (C) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：365 / 372

页数：8

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