Gray zones in brain tumor classification - Evolving concepts

被引:22
作者
Trembath, Dimitri [3 ]
Miller, Christopher Ryan [2 ]
Perry, Arie [1 ]
机构
[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA
关键词
classification; glioma; oligodendroglioma; meningioma; medulloblastoma; ependymoma; World Health Organization;
D O I
10.1097/PAP.0b013e3181836a03
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The World Health Organization recently updated its classification of central nervous system tumors, adding 8 entities, as well as defining new variants and morphologic patterns of existing entities. Despite the continued refinement of brain tumor histologic classification and grading, there remain some diagnostic "gray zones" that challenge general surgical pathologists and neuropathologists alike. These include the presence of oligodendroglial features in (mixed) oligoastrocytomas and glioblastomas (GBMs), GBM variants (such as small cell GBM), meningioma classification and grading, medulloblastoma variants, ependymoma grading, the presence of "neuronal features" in otherwise morphologically classic gliomas, and low-grade gliomas with high Ki-67 labeling indices. In the current review, we discuss these issues and offer some practical guidelines for dealing with problematic cages.
引用
收藏
页码:287 / 297
页数:11
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