Age-dependent atrial remodeling induced by recombinant human interleukin-11: Implications for atrial flutter/fibrillation

被引:19
作者
Xu, J
Ren, JF
Mugelli, A
Belardinelli, L
Keith, JC
Pelleg, A
机构
[1] Med Coll Penn & Hahnemann Univ, Philadelphia, PA 19012 USA
[2] Genet Inst Inc, Andover, MA USA
[3] CV Therapeut, Palo Alto, CA USA
[4] Univ Florence, Florence, Italy
关键词
AF; aging; atrial remodeling; interleukin; 11; refractoriness;
D O I
10.1097/00005344-200203000-00015
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Recombinant human interleukin-11 (rhIL-11) has been used to alleviate side effects caused by chemotherapy in patients with neoplastic diseases and as an experimental anti-inflammatory agent. Its use in elderly patients has been associated with increased frequency of atrial flutter/fibrillation (AF). The mechanism of the latter phenomenon was studied in a rat model in vivo. Adult and old Fischer 344 rats fed with either normal diet or sodium-restricted diets were treated with rhIL-11 or vehicle (control) (1 mg/kg/day, i.p., 7 days); cardiac electrophysiologic parameters and atrial dimensions were determined. In adult rats, rhIL-11 was without effect, and atrial pacing did not induce AF. In contrast, in old rats, rhIL-11 shortened atrial refractoriness and increased atrial dimensions. Also, atrial pacing induced AF in old rats treated with rhIL-11 more than in controls. These effects of rhIL-11 in old rats were reversed by sodium-restricted diet. It was concluded that rhIL-11 induces age-dependent atrial remodeling manifested by atrial stretch and reduced atrial refractoriness, which favor AF. Na retention is the most likely mechanism underlying this effect of rhIL-11.
引用
收藏
页码:435 / 440
页数:6
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