Nanoparticles for cancer imaging: The good, the bad, and the promise

被引：119

作者：

Chapman, Sandra ^{[1
]}

Dobrovolskai, Marina ^{[2
]}

Farahani, Keyvan ^{[3
]}

Goodwin, Andrew ^{[4
]}

Joshi, Amit ^{[5
,6
]}

Lee, Hakho ^{[7
]}

Meade, Thomas ^{[8
,9
,10
]}

Pomper, Martin ^{[11
]}

Ptak, Krzysztof ^{[12
]}

Rao, Jianghong ^{[13
]}

Singh, Ravi ^{[14
]}

Sridhar, Srinivas ^{[15
,16
]}

Stern, Stephan ^{[2
]}

Wang, Andrew ^{[17
]}

Weaver, John B. ^{[18
]}

Woloschak, Gayle ^{[19
,20
,21
]}

Yang, Lily ^{[22
]}

机构：

[1] NCI, Off Canc Nanotechnol Res, Ctr Strateg Sci Initiat, NIH, Bethesda, MD 20892 USA

[2] SAIC Frederick Inc, Nanotechnol Characterizat Lab, Adv Technol Res Facil, Frederick Natl Lab Canc Res, Frederick, MD 21702 USA

[3] NCI, Image Guided Intervent Branch, Canc Imaging Program, Rockville, MD 20852 USA

[4] Univ Colorado Boulder, Dept Chem & Biol Engn, Boulder, CO 80303 USA

[5] Baylor Coll Med, Dept Radiol, TBMM Grad Program, Houston, TX 77030 USA

[6] Baylor Coll Med, Dept Mol Physiol & Biophys, TBMM Grad Program, Houston, TX 77030 USA

[7] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Syst Biol, Boston, MA 02114 USA

[8] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[9] Northwestern Univ, Dept Mol Biosci, Evanston, IL 60208 USA

[10] Northwestern Univ, Dept Radiol, Evanston, IL 60208 USA

[11] Johns Hopkins Med Sch, Baltimore, MD 21287 USA

[12] NCI, Off Canc Ctr, Off Director, NIH, Bethesda, MD 20892 USA

[13] Stanford Univ, Mol Imaging Program Stanford, Dept Radiol, Stanford, CA 94305 USA

[14] Wake Forest Sch Med, Dept Canc Biol, Winston Salem, NC 27157 USA

[15] Northeastern Univ, Nanomedicine Sci & Technol Ctr, Boston, MA 02115 USA

[16] Northeastern Univ, Dept Phys, Boston, MA 02115 USA

[17] Univ N Carolina, Dept Radiat Oncol, Carolina Ctr Nanotechnol Excellence, Chapel Hill, NC 27599 USA

[18] Dartmouth Coll, Geisel Sch Med, Dept Radiol, Hanover, NH 03755 USA

[19] Northwestern Univ, Dept Radiat Oncol, Robert E Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[20] Northwestern Univ, Dept Radiol, Robert E Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[21] Northwestern Univ, Dept Cell & Mol Biol, Robert E Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[22] Emory Univ Sch Med, Dept Surg, Atlanta, GA 30322 USA

来源：

NANO TODAY | 2013年 / 8卷 / 05期

关键词：

Nanonnedicine; Cancer; Imaging; Detection; Screening; PARTICLES; CLEARANCE; MOLECULES;

D O I：

10.1016/j.nantod.2013.06.001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Recent advances in molecular imaging and nanotechnology are providing new opportunities for biomedical imaging with great promise for the development of novel imaging agents. The unique optical, magnetic, and chemical properties of materials at the scale of nanometers allow the creation of imaging probes with better contrast enhancement, increased sensitivity, controlled biodistribution, better spatial and temporal information, multi-functionality and multi-modal imaging across MRI, PET, SPECT, and ultrasound. These features could ultimately translate to clinical advantages such as earlier detection, real time assessment of disease progression and personalized medicine. However, several years of investigation into the application of these materials to cancer research has revealed challenges that have delayed the successful application of these agents to the field of biomedical imaging. Understanding these challenges is critical to take full advantage of the benefits offered by nano-sized imaging agents. Therefore, this article presents the lessons learned and challenges encountered by a group of leading researchers in this field, and suggests ways forward to develop nanoparticle probes for cancer imaging. Published by Elsevier Ltd.

引用

页码：454 / 460

页数：7

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