Altered functional MRI responses in Huntington's disease

被引：29

作者：

Clark, VP

Lai, S

Deckel, AW

机构：

[1] Univ Connecticut, Sch Med, Dept Psychiat, Farmington, CT 06030 USA

[2] Univ Connecticut, Sch Med, Program Neurosci, Farmington, CT 06030 USA

[3] Univ Connecticut, Sch Med, Dept Diagnost Imaging & Therapeut, Farmington, CT 06030 USA

[4] Hartford Hosp, Huntingtons Dis Program, Hartford, CT 06106 USA

来源：

NEUROREPORT | 2002年 / 13卷 / 05期

关键词：

brain mapping; cerebral blood flow; cognition; fMRI; Huntington's disease; magnetic resonance imaging; neuroimaging; striatum; visual cortex;

D O I：

10.1097/00001756-200204160-00033

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study examined the effects of Huntington's disease (HD) on neural activity during performance of the Porteus maze task. fMRI data were acquired from three HD patients and three controls. Reduced fMRI signal was observed in the patients relative to the controls in occipital, parietal and somato-motor cortex and in the caudate, while increased signal was found in HID in the left postcentral and right middle frontal gyri. The altered fMRI responses in HD patients may result from neural, metabolic, neurovascular coupling and/or hemodynamic differences associated with this disorder.

引用

收藏

页码：703 / 706

页数：4

相关论文

共 25 条

[1]

[Anonymous], HUM BRAIN MAP S

[2] Striatal glucose metabolism and dopamine D-2 receptor binding in asymptomatic gene carriers and patients with Huntington's disease [J].

Antonini, A ;

Leenders, KL ;

Spiegel, R ;

Meier, D ;

Vontobel, P ;

WeigellWeber, M ;

SanchezPernaute, R ;

deYebenez, JG ;

Boesiger, P ;

Weindl, A ;

Maguire, RP .

BRAIN, 1996, 119 :2085-2095

[3] POSITRON EMISSION TOMOGRAPHIC SCAN INVESTIGATIONS OF HUNTINGTONS-DISEASE - CEREBRAL METABOLIC CORRELATES OF COGNITIVE FUNCTION [J].

BERENT, S ;

GIORDANI, B ;

LEHTINEN, S ;

MARKEL, D ;

PENNEY, JB ;

BUCHTEL, HA ;

STAROSTARUBINSTEIN, S ;

HICHWA, R ;

YOUNG, AB .

ANNALS OF NEUROLOGY, 1988, 23 (06) :541-546

[4] Reduced activity and protein expression of NOS in R6/2 HD transgenic mice: effects of L-NAME on symptom progression [J].

Deckel, AW ;

Gordinier, A ;

Nuttal, D ;

Tang, V ;

Kuwada, C ;

Freitas, R ;

Gary, KA .

BRAIN RESEARCH, 2001, 919 (01) :70-81

[5] Vasomotor hyporeactivity in the anterior cerebral artery during motor activation in Huntington's disease patients [J].

Deckel, AW ;

Duffy, JD .

BRAIN RESEARCH, 2000, 872 (1-2) :258-261

[6] Dietary arginine alters time of symptom onset in Huntington's disease transgenic mice [J].

Deckel, AW ;

Volmer, P ;

Weiner, R ;

Gary, KA ;

Covault, J ;

Sasso, D ;

Schmerler, N ;

Watts, D ;

Yan, Z ;

Abeles, I .

BRAIN RESEARCH, 2000, 875 (1-2) :187-195

[7] Cerebral blood flow velocity decreases during cognitive stimulation in Huntington's disease [J].

Deckel, AW ;

Cohen, D ;

Duckrow, R .

NEUROLOGY, 1998, 51 (06) :1576-1583

[8]

Deckel AW, 2000, J NUCL MED, V41, P773

[9] Multimodal imaging of residual function and compensatory resource allocation in cortical atrophy:: a case study of parietal lobe function in a patient with Huntington's disease [J].

Dierks, T ;

Linden, DEJ ;

Hertel, A ;

Günther, T ;

Lanfermann, H ;

Niesen, A ;

Frölich, L ;

Zanella, FE ;

Hör, G ;

Goebel, R ;

Maurer, K .

PSYCHIATRY RESEARCH-NEUROIMAGING, 1998, 84 (01) :27-35

[10] PET imaging of maze processing [J].

Flitman, S ;

OGrady, J ;

Cooper, V ;

Grafman, J .

NEUROPSYCHOLOGIA, 1997, 35 (04) :409-420