A possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer

被引：360

作者：

Toprak, N. Ulger

Yagci, A.

Gulluoglu, B. M.

Akin, M. L.

Demirkalem, P.

Celenk, T.

Soyletir, G.

机构：

[1] Marmara Univ, Sch Med, Dept Clin Microbiol, Istanbul, Turkey

[2] Marmara Univ, Sch Med, Dept Gen Surg, Istanbul, Turkey

[3] Haydarpasa Teaching Hosp, Gulhane Mil Med Acad, Dept Gen Surg, Istanbul, Turkey

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2006年 / 12卷 / 08期

关键词：

Bacteroides fragilis; bft gene; colorectal cancer; enterotoxin; fragilysin; PCR;

D O I：

10.1111/j.1469-0691.2006.01494.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The prevalence of enterotoxigenic Bacteroides fragilis (ETBF) was investigated in stool specimens from 73 patients with colorectal cancer and from 59 control patients. Stool specimens were cultured on Bacteroides Bile Esculin agar and B. fragilis was identified by conventional methods. After DNA extraction, the enterotoxin gene (bft) was detected by PCR in 38% of the isolates from colorectal cancer patients, compared with 12% of the isolates from the control group (p 0.009). This is the first study demonstrating an increased prevalence of ETBF in colorectal cancer patients.

引用

页码：782 / 786

页数：5

共 23 条

[1] Are Helicobacter species and enterotoxigenic Bacteroides fragilis involved in inflammatory bowel disease? [J].