Antiendotoxin strategies

被引：30

作者：

Hellman, J

Warren, HS

机构：

[1] Harvard Univ, Sch Med, Boston, MA USA

[2] Massachusetts Gen Hosp, Dept Anesthesia & Crit Care, Boston, MA 02114 USA

[3] Massachusetts Gen Hosp, Infect Dis Unit, Boston, MA 02114 USA

来源：

INFECTIOUS DISEASE CLINICS OF NORTH AMERICA | 1999年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0891-5520(05)70080-5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Endotoxin is a potent stimulator of the inflammatory response and is believed to initiate the pathology in Gram-negative sepsis. Agents are being developed that bind and neutralize or block the effects of endotoxin, with the goal of improving outcome in the treatment of sepsis. Strategies discussed in this article include anti-LPS antibodies, LPS binding proteins and lipoproteins, poly myxin B conjugates, Lipid A analogues, and extracorporeal techniques for endotoxin removal.

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页码：371 / +

页数：17

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