New insights in the structure and biology of the high affinity receptor for IgE (Fc epsilon RI) on human epidermal Langerhans cells

被引：24

作者：

Bieber, T ^{[1
]}

Kraft, S ^{[1
]}

Jurgens, M ^{[1
]}

Strobel, I ^{[1
]}

Haberstok, J ^{[1
]}

Tomov, H ^{[1
]}

Regele, D ^{[1
]}

delaSalle, H ^{[1
]}

Wollenberg, A ^{[1
]}

Hanau, D ^{[1
]}

机构：

[1] ETAB REG TRANSFUS SANGUINE, STRASBOURG, FRANCE

来源：

JOURNAL OF DERMATOLOGICAL SCIENCE | 1996年 / 13卷 / 01期

关键词：

high affinity receptor; Fc epsilon RI; Langerhans cells; IgE;

D O I：

10.1016/0923-1811(95)00504-8

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The recent structural and functional analysis of the high affinity receptor for IgE (Fc epsilon RI) expressed on human epidermal Langerhans cells (LC) revealed new aspects of the biology of this structure. In contrast to basophils and mast cells where this receptor seems to be expressed constitutively at a constant level, the expression of Fc epsilon RI on LC varies on the donor and the inflammatory environment of the cells and lacks the classical beta-chain. This also implies functional differences most probably related to the expression level. Although the signalling pathway seems to be similar to that of basophils or mast cells, LC from individuals with atopic dermatitis are fully activated by receptor ligation while LC from normal individuals fail to exhibit calcium mobilization under the same conditions. Finally, LC from normal and atopic individuals use Fc epsilon RI to maximize antigen uptake via specific IgE and subsequent presentation to T cells. Thus, Fc epsilon RI expressed on LC differs in terms of structure and function From that expressed on effector cells of anaphylaxis.

引用

页码：71 / 75

页数：5

共 20 条

[1] OCCURRENCE OF IGE-BEARING EPIDERMAL LANGERHANS CELLS IN ATOPIC ECZEMA - A STUDY OF THE TIME COURSE OF THE LESIONS AND WITH REGARD TO THE IGE SERUM LEVEL [J].