A novel lanthanide complex with remarkable phosphodiester transesterification activity and DNA-conjugatable functionality

被引：8

作者：

Baykal, U ^{[1
]}

Akkaya, MS ^{[1
]}

Akkaya, EU ^{[1
]}

机构：

[1] Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey

来源：

JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY | 1999年 / 35卷 / 1-2期

关键词：

artificial enzymes; phosphodiester hydrolysis; RNA hydrolysis; lanthanide complexes;

D O I：

10.1023/A:1008111418731

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Encapsulated lanthanide complexes like the TCMC complexes are highly stable under physiological conditions. With the ultimate goal being an in vivo application of these complexes as a sequence-selective RNA/DNA cleaving agent (artificial RNAse/DNAse), kinetic stability of the complex would be a distinct advantage. We have synthesized a novel lanthanide complex with such stability and which displays high transesterification activity. The most important attribute of this compound is the nitrophenyl group which would allow further derivatization and conjugation to a DNA oligomer, thus creating a potential for the sequence selective hydrolysis of its target.

引用

页码：311 / 315

页数：5

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