A v-SNARE implicated in intra-Golgi transport

被引：94

作者：

Nagahama, M

Orci, L

Ravazzola, M

Amherdt, M

Lacomis, L

Tempst, P

Rothman, JE

Sollner, TH

机构：

[1] MEM SLOAN KETTERING CANC CTR,CELLULAR BIOCH & BIOPHYS PROGRAM,NEW YORK,NY 10021

[2] MEM SLOAN KETTERING CANC CTR,PROGRAM MOLEC BIOL,NEW YORK,NY 10021

[3] UNIV GENEVA,CTR MED,DEPT MORPHOL,INST HISTOL & EMBRYOL,CH-1211 GENEVA 4,SWITZERLAND

来源：

JOURNAL OF CELL BIOLOGY | 1996年 / 133卷 / 03期

关键词：

D O I：

10.1083/jcb.133.3.507

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We report the identification of a putative v-SNARE (GOS-28), localized primarily to transport vesicles at the terminal rims of Golgi stacks. In vitro, GOS-28, a Golgi SNARE of 28 kD, is efficiently packaged into Golgi-derived vesicles, which are most likely COPI coated. Antibodies directed against GOS-28 block its ability to bind alpha-SNAP, partially inhibit transport from the cis to the medial cisternae, and do not inhibit budding of COP-coated vesicles, but do accumulate docked uncoated vesicles.

引用

页码：507 / 516

页数：10

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