The endocrine profile of subcutaneous and visceral adipose tissue of obese patients

被引：74

作者：

Dolinkova, M. ^{[1
]}

Dostalova, I. ^{[1
]}

Lacinova, Z. ^{[1
]}

Michalsky, D. ^{[1
,2
]}

Haluzikova, D. ^{[1
,3
]}

Mraz, M. ^{[1
]}

Kasalicky, M. ^{[1
,2
]}

Haluzik, M. ^{[1
]}

机构：

[1] Gen Univ Hosp, Prague, Czech Republic

[2] Charles Univ Prague, Fac Med 1, Dept Surg, Prague 12808 2, Czech Republic

[3] Charles Univ Prague, Fac Med 1, Dept Sports Med, Prague 12808 2, Czech Republic

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2008年 / 291卷 / 1-2期

关键词：

obesity; metabolic syndrome; subcutaneous adipose tissue; visceral adipose tissue; isolated adipocytes; gene expression;

D O I：

10.1016/j.mce.2008.05.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The aim of the present study was to evaluate the expression profile of genes potentially related to metabolic complications of obesity in the whole adipose tissue and isolated adipocytes from subcutaneous (SAT) and visceral adipose tissue (VAT) from 12 non-diabetic obese women and 12 lean women. Real-time polymerase chain reaction was used for expression analysis of 41 genes of interest and two housekeeping genes. We found increased expression of specific proinflammatory and adipogenic genes and reduced expression of specific lipogenic and insulin signaling pathway genes in obese relative to lean women with no preferable localization in SAT or VAT depot. The gene expression significantly differed between adipocytes and adipose tissue but both contributed to the proinflammatory profile in obesity. We conclude that both SAT and VAT exhibit alterations in the expression of specific genes possibly contributing to proinflammatory and insulin resistance state and consequently to metabolic complications of obesity. (c) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：63 / 70

页数：8

共 32 条

[1] RELATIONSHIPS OF GENERALIZED AND REGIONAL ADIPOSITY TO INSULIN SENSITIVITY IN MEN [J].