Cadinane sesquiterpenes from the leaves of Eupatorium adenophorum

被引：49

作者：

He, Lan ^{[1
]}

Hou, Jing ^{[1
]}

Gan, Maoluo ^{[2
,3
]}

Shi, Jiangong ^{[2
,3
]}

Chantrapromma, Suchada ^{[4
]}

Fun, Hoong-Kun ^{[5
]}

Williams, Ian D. ^{[6
]}

Sung, Herman H. -Y. ^{[6
]}

机构：

[1] Beijing Normal Univ, Dept Chem, Beijing 100875, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Key Lab Bioact Subst & Resources Utilizat Chinese, Minist Educ, Beijing 100050, Peoples R China

[4] Prince Songkla Univ, Fac Sci, Dept Chem, Hat Yai 90112, Songkhla, Thailand

[5] Univ Sains Malaysia, Sch Phys, Xray Crystallog Unit, George Town 11800, Malaysia

[6] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2008年 / 71卷 / 08期

基金：

北京市自然科学基金; 中国国家自然科学基金;

关键词：

D O I：

10.1021/np800242w

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new cadinane sesquiterpenes (1-4), including a dimeric cadinane derivative (2) and a peroxide cadinane analogue (3), have been isolated from the leaves of Eupatorium adenophorum. Their Structures including absolute configurations were determined oil the basis of spectroscopic data interpretation and single-crystal X-ray crystallography. Compound 4 showed in vitro cytotoxicity against the HCT-8, Bel-7402, and A2780 cancer cell lines.

引用

页码：1485 / 1488

页数：4

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