Contribution of distinct adhesive interactions to platelet aggregation in flowing blood

被引:217
作者
Ruggeri, ZM
Dent, JA
Saldívar, E
机构
[1] Scripps Res Inst, Roon Res Ctr Arteriosclerosis & Thrombosis, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Div Expt Hemostasis & Thrombosis, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Dept Mol & Expt Med, La Jolla, CA 92037 USA
[4] Scripps Res Inst, Dept Vasc Biol, La Jolla, CA 92037 USA
关键词
D O I
10.1182/blood.V94.1.172.413k17_172_178
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aggregation of blood platelets contributes to the arrest of bleeding at sites of vascular injury, but it can occlude atherosclerotic arteries and precipitate diseases such as myocardial infarction. The bonds that link platelets under flow conditions were identified using confocal videomicroscopy in real time. Glycoprotein (GP) Ib alpha and von Willebrand factor (VWF) acted in synergy with alpha(IIb)beta(3) and fibrinogen to sustain platelet accrual at the apex of thrombi where three-dimensional growth resulted in increasing shear rates. The specific function of distinct adhesion pathways in response to changing hemodynamic conditions helps to explain hemostatic and thrombotic processes. (C) 1999 by The American Society of Hematology.
引用
收藏
页码:172 / 178
页数:7
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