Role of osteoclasts and interleukin-17 in the pathogenesis of rheumatoid arthritis: crucial 'human osteoclastology'

被引：66

作者：

Kotake, Shigeru ^{[1
]}

Yago, Toru ^{[1
]}

Kawamoto, Manabu ^{[1
]}

Nanke, Yuki ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Inst Rheumatol, Shinjuku Ku, Tokyo 1620054, Japan

来源：

JOURNAL OF BONE AND MINERAL METABOLISM | 2012年 / 30卷 / 02期

关键词：

Interleukin-17 (IL-17); Osteoclast; Osteoclastology; Th17; Rheumatoid arthritis; COLONY-STIMULATING FACTOR; ACTIVATED T-CELLS; DIRECTLY INDUCE OSTEOCLASTOGENESIS; COLLAGEN-INDUCED ARTHRITIS; BONE-MARROW ADJACENT; RECEPTOR ACTIVATOR; UP-REGULATION; SOLUBLE INTERLEUKIN-6; OSTEOTROPIC HORMONES; MONOCLONAL-ANTIBODY;

D O I：

10.1007/s00774-011-0321-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Many papers have reported that osteoclasts play an important role in the pathogenesis of rheumatoid arthritis (RA); however, when we started to investigate the pathogenesis of RA, the roles of osteoclasts were not highlighted in RA bone resorption. In recent years, the number of articles on the roles of osteoclasts and interleukin (IL)-17 in the pathogenesis of RA has increased exponentially. In this review article, we describe our articles on the roles of osteoclasts and IL-17 in joint destruction in RA, from 1990 to 2011, and highlight a novel term, 'human osteoclastology', which we have used since 2008.

引用

页码：125 / 135

页数：11

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