Novel quinolinequinone antitumor agents:: Structure-metabolism studies with NAD(P)H:quinone oxidoreductase (NQO1)

被引：34

作者：

Fryatt, T

Goroski, DT

Nilson, ZD

Moody, CJ

Beall, HD ^{[1
]}

机构：

[1] Univ Montana, Dept Pharmaceut Sci, Missoula, MT 59812 USA

[2] Univ Exeter, Sch Chem, Exeter EX4 4QD, Devon, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(99)00369-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The effects of functional group changes on the metabolism of novel quinolinequinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1) are described. Overall, the quinolinequinones were much better substrates for NQO1 than analogous indolequinones, with compounds containing heterocyclic substituents at C-2 being among the best substrates. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2195 / 2198

页数：4

共 23 条

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